HARMONY

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Product Details

HARMONY is designed to support hormone balance in those experiencing perimenopause and menopause.* It may help ease discomfort experienced by women during this transitional period.*

SIZE 60 Vegetable Capsules

SERVING SIZE 2 Capsules

SERVINGS PER CONTAINER 30

DIRECTIONS Take 2 capsules once per day or as directed by your healthcare practitioner.

INGREDIENTS

200mg of Chasteberry
150mg of Ashwaganda
100mg of Black Cohosh
100mg of Grape Seed Extract
100mg of Wild Yam
70mg of Maritime Pine
50mg of Rhodiola Rosea

PRIMARY INDICATIONS FOR USE

Perimenopause and menopause*
History of blood clots with HRT*
Poor response to HRT*
Exacerbation of symptoms or side effects with HRT*
Family history of hormone related cancer*

This formula does not JUST support the symptoms of night sweats and hot flashes. It also supports mood swings, decreased libido, soreness, dryness, headaches, bloating, fatigue, inflammation, joint pain, memory and concentration issues, brittle nails, thinning hair, weight gain, anxiety and irritability.*

OTHER INGREDIENTS Hydroxypropyl methylcellulose (vegetable capsule), microcrystalline cellulose, l-leucine, bamboo silica.

DOES NOT CONTAIN Milk, eggs, fish, shellfish, peanuts, tree nuts, wheat, soy.

CAUTION If you are pregnant, nursing or taking any medications, consult your doctor before use. Keep out of reach of children.

STORAGE Keep tightly closed in a cool, dry place.

*These statements have not been evaluated by the Food and Drug Administration. These products are not intended to diagnose, treat, cure or prevent any disease.

WANT TO DIVE DEEPER?

Chaste Tree Extract (Vitex Angus)(200mg)

Research suggest that chasteberry might help reduce menopausal symptoms reducing the frequency of hot flashes and night sweats and improving your mood
This may be because chasteberry contains Phytoestrogens, natural substances that mimic estrogen

Study: Comparison of Vitex Agnus extracts with placebo in reducing menopausal symptoms. A randomized Double-Blind study.

This study was a randomized controlled double-blind clinical trial with a study group of 52 women referred to a clinic in Kermanshah in 2017. The participants were randomly divided in two groups. Vitex Group (26 subjects) and placebo group (26 subjects). Menopausal symptoms were assessed using the Greene Scale before and 8 weeks after the intervention.
After the intervention, the mean scores for total menopausal disorder, anxiety, and Vasomotor dysfunction were significantly lower in the Vitex group than the placebo group (P<0.05). The mean scores of the variables of somatic complications, depression, and sexual dysfunction did not show significant differences between the Vitex and placebo groups.
Published online 2019 May 9. doi: 10.4082/kjfm.18.0067 PMCID: PMC6887765

Black Cohosh (Camicifuga racemosa)(100mg)

Studies confirm that black cohosh is effective for relieving menopausal symptoms. Early German studies found black cohosh improved physical and psychological menopausal symptoms, including anxiety, hot flashes, night sweats and vaginal dryness
The herb has been widely used in Europe for more than 40 years and is approved in Germany for premenstrual discomfort, painful menstruation, and menopausal women.

Study 1: Benefits of Black Cohosh for Women Health: An up-close and in-depth review

The present review clearly encapsulates the use of Cimicifuga racemosa extract for effective and safe therapy to alleviate menopausal symptoms. CR can be used successful as a potential alternative to HRT in adult women
Pharmaceuticals 2022, 15(3), 278; https://doi.org/10.3390/ph15030278

Study 2: Effect on black cohosh on vasomotor symptoms in post-menopausal women: a randomized clinical trial

This was a randomized, double-blind, placebo-controlled clinical trial. This study was performed on 84 postmenopausal women. The participants were randomly divided into control and intervention groups. The participants of the intervention group received one black cohosh tablet per day and the control group received one placebo tablet per day for eight weeks. The severity of vasomotor symptoms and number of hot flashes were recorded during the pre- intervention phase, and 4 and 8 weeks after the intervention. The data were analyzed using repeated measures ANOVA and ANCOVA tests. The level of significance was considered lower than 0.05.
Moreover, using repeated measures ANOVA, the intergroup comparison indicated a significant difference in both groups (the test and control groups) in terms of severity of vasomotor symptoms and number of hot flashes.
According to the findings of the study, it seems that black cohosh can be used as an effective alternative medicine in relieving menopausal vasomotor symptoms.
PMID: 25276716 PMCID: PMC4161092 DOI: 10.5681/jcs.2013.013

Wild Yam (100mg)

A double-blind placebo-controlled trial of 13 peri-and post-menopausal women in 1997 found that those taking wild yam combined with other herbs experienced a reduction in the number and severity of menopausal symptoms, such as hot flushes, mood changes and insomnia.
A 2013 study published in BMC Complementary and Alternative Medicine concluded that a daily dried extract of wild yam significantly reduced inflammatory markers in the blood samples of mice with medically- induced inflammation.

Study: Estrogenic Effect of yam ingestion in healthy post-menopausal women

Yam (Dioscorea) has been used to treat menopausal symptom folklorically. This study was to investigate the effects of yam ingestion on lipids, antioxidant status, and sex hormones in postmenopausal women.
Twenty-four apparently healthy postmenopausal women were recruited to replace their staple food (rice for the most part) with 390 g of yam (Dioscorea alata) in 2 of 3 meals per day for 30 days and 22 completed the study. Fasting blood and first morning urine samples were collected before and after yam intervention for the analyses of blood lipids, sex hormones, urinary estrogen metabolites and oxidant stress biomarker. The design was a one arm, pre-post study. A similar study of postmenopausal women (n = 19) fed 240 g of sweet potato for 41 days
Results: After yam ingestion, there were significant increases in serum concentrations of estrone (26%), sex hormone binding globulin (SHBG) (9.5%), and near significant increase in estradiol (27%).
Urinary concentrations of the genotoxic metabolite of estrogen, 16alpha-hydroxyestrone decreased significantly by 37%
Conclusion: Although the exact mechanism is not clear, replacing two thirds of staple food with yam for 30 days improves the status of sex hormones, lipids, and antioxidants. These effects might reduce the risk of breast cancer and cardiovascular diseases in postmenopausal women.
PMID: 16093400 DOI: 10.1080/07315724.2005.10719470

Rhodolia (50mg)

Menopause is associated with increased risks for cardiovascular disease, osteoporosis, and cancer. Many women experience declining energy, mood, cognitive function, and memory during menopause.
Rhodiola rosea extracts have been shown to enhance mood, cognitive function, and memory. Moreover, these extracts possess anti-stress, neuroprotective, cardiovascular- protective, and anti-carcinogenic properties, which are particularly valuable to counteract some of the common health risks seen in women

Ashwagandha (150mg)

Ashwagandha may alleviate some menopause symptoms, such as hot flashes and urinary symptoms
Ninety-one women completed the eight-week trial, in which 46 participants were given 300 mg of ashwagandha root extract twice per day, while the remainder received a twice-daily placebo. Participants rated the severity of their hot flashes in a daily symptom diary and scored other menopause symptoms using menopause symptom rating questionnaires.
The ashwagandha group reported significant improvements in many of their symptoms, including hot flashes, by four weeks.

Study: Effect of an ashwagandha (Withania Somnifera) root extract on climacteric symptoms in women during perimenopause:

A randomized, double-blind, placebo-controlled study

Among 100 participants enrolled, 91 participants completed the study. In comparison with the placebo, ashwagandha supplementation was associated with a statistically significant reduction in total MRS score, reflected by significant reductions in the psychological, somato- vegetative, and urogenital domains. Ashwagandha intake demonstrated a statistically significant reduction in total MENQoL scores and was also associated with a statistically significant increase in serum estradiol and a significant reduction in serum FSH and serum LH compared with the placebo. There was no significant between the group differences in the serum testosterone level.
These findings suggest that ashwagandha root extract can be a safe and effective option to relieve mild to moderate climacteric symptoms during perimenopause in women.
2021 Dec;47(12):4414-4425. doi: 10.1111/jog.15030. Epub 2021 Sep 22

Grape Seed Extract (100mg)

Study: Effects of grape seed proanthocyanidin extract on menopausal symptoms, body composition, and cardiovascular parameters in middle-aged women: a randomized, double-blind, placebo-controlled pilot study

A total of 91 women (95%) completed the study. Background characteristics, including age, menopause status, subjective symptom scores, body composition, and cardiovascular parameters, were similar among the groups.
The following significant changes were observed during the course of the study: (1) physical symptom score, hot flash score, and (2) Athens Insomnia Scale score decreased in the high-dose group after 8 weeks of treatment; (3) Hospital Anxiety and Depression Scale Anxiety score and (4) systolic and diastolic blood pressure decreased in the low-dose and high-dose groups after 4 weeks; and, (5) lastly, muscle mass increased in the low-dose and high-dose groups after 8 weeks of treatment.
Conclusions: Grape seed proanthocyanidin extract is effective in improving the physical and psychological symptoms of menopause while increasing muscle mass and reducing blood pressure in middle-aged women.
Menopause 2014 Sep;21(9):990-6. doi: 10.1097/GME.0000000000000200.

Maritime Pine (Pinus Pinaster) (70mg)

Pycongenol provides significant benefit for supporting unpleasant symptoms of menopause:
Decreases hot flashes*
Supports good mood and anxious feelings*
Improves fatigue commonly associated with menopause*
Promotes skin elasticity*
Promotes good cognitive function and memory*
Supports cardiovascular health, which can suffer with menopause*
Reduces night sweats and other sleep disturbances*

Study 1: Effect of low-dose French maritime pine bark extract on climacteric syndrome in 170 perimenopausal women: a randomized, double-blind, placebo-controlled trial

In a double-blind, placebo-controlled study 170 perimenopausal women were enrolled and treated with 30 mg Pycnogenol or placebo twice daily over a period of 3 months. Climacteric symptoms were evaluated by the Women's Health Questionnaire (WHQ) and by the Kupperman index, accompanied by an investigation of sex hormones and routine blood chemistry.
Results: Compared to baseline, Pycnogenol significantly (p < 0.05) improved all symptoms with the exception of formication sensation and abnormal perceptions. Pycnogenol was found to be especially effective for improving vasomotor and insomnia/sleep problem symptoms, which were significantly better after 4 and 12 weeks than with placebo (p < 0.05)
PMID: 23447917
Conclusion: This study, applying a relatively low daily dose, allows identification of those climacteric symptoms which respond particularly well to supplementation with Pycnogenol.

Study 2: Normalization of cardiovascular risk factors in peri-menopausal women with Pycnogenol

The aim of the study was the evaluation of the efficacy of Pycnogenol® in peri-menopausal women in controlling homocysteine and C-reactive protein (CRP) levels, borderline cardiovascular risk factors, oxidative stress (OS) and symptoms associated to menopausal transition (MT).
Methods: Pycnogenol®, 100mg/day, was used as a supplement for 8 weeks by a group of 35 women. A comparable group of 35 women with identical cardiovascular risk factors was included as the control group. All women were instructed to participate in a best management plan of menopause.
Results: Supplementation with Pycnogenol® decreased the slightly elevated cholesterol and triglycerides after 8 weeks (P<0.05). Also, the fasting glucose levels were normalized (P<0.05). The borderline increased blood pressure was reduced to normal values at 8 weeks (P<0.05). Plasma free radicals dropped significantly by 22% (P<0.05). Homocysteine and CRP levels decreased sharply by 43% and 60%, respectively (P<0.05).
PMID: 28116886 DOI: 10.23736/S0026-4784.16.03913-7

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